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CIMR Nationally Recognized Research

More than 300 research programs have been conducted at CIMR by award winning researchers.  This has resulted in nationally recognized discoveries in medicine and medical care. These have included:

  • improving the treatment of fungal diseases such as Valley Fever
  • preventing recurrent heart attack and stroke
  • developing an animal model of Parkinson’s disease
  • studying the influence of genetics on developing cancer.
  • identifying naturally-occuring organic compounds with anti-cancer activity (from nutritional studies in cancer)
  • investigating immune restoration by biological antioxidants (such as lipoic acid) in AIDS (from nutritional studies in AIDS)

labCIMR researchers have also advanced the understanding of how the brain and spinal cord respond to neurological disorders, and developed a direct physiologic measurement of neurological processes that are critical to recovery from stroke and traumatic brain injury.

In addition, HIV physician-researchers have provided SCVMC patients access to clinical trial studies, including adherence and treatment strategies, prophylaxis and treatment of various opportunistic infections, and viral vaccine trials.lab

The Neurology Research Laboratory has completed a series of experiments demonstrating substantial neuroplasticity of the part of the adult brain that produces vision. These findings suggest an intrinsic mechanism that can potentially help repair visual loss after stroke or injury to the visual brain.

The Infectious Diseases Laboratory continues to make significant progress in the treatment of fungal infections, performing in vitro and in vivo studies on novel compounds and testing licensed conventional antifungals alone and in combination.  Studies of molecular epidemiology of the mycoses, of host defenses against fungal infections (including the possibility of immunomodulation) and of vaccine development are areas of extensive effort.

Research Highlight

Injecting mice with simple baker’s yeast protects against the fatal fungal infection, aspergillosis, according to research published in the Journal of Medical Microbiology. The work could lead to the development of a human vaccine that protects immunocompromised people against a range of life-threatening fungal infections, for which current therapy often fails.

Researchers from the California Institute for Medical Research (Dr. David Stevens' research team), Santa Clara Valley Medical Center and Stanford University gave mice three injections of killed Saccharomyces (baker’s yeast), one week apart. Vaccinated mice were able to survive high doses of Aspergillus – the fungus that causes aspergillosis. Mice that survived also showed a reduced infection load in their organs. To view full press release, click here

Winners of grant

David Stevens, MD, receiving the Lucille Georg Medal from the
International Society for Animal and Human Mycology (SHAM) in 2006.

From left: David Stevens, MD (CIMR Board President); Malcolm Richardson, Helsinki, Finland, Gen. Sec. of the International Society for Animal and Human Mycology (ISHAM); and David Warnock, US Centers for Disease Control, Atlanta, President of ISHAM.

Notes for Researchers - Research Grant Administration

CIMR’s administration office is responsible for the administration of research grants. This includes:

  • helping find funding opportunities
  • assisting investigators with the preparation and submission of proposal applications,
  • working with sponsors and collaborating institutions to negotiate contract and award terms,
  • monitoring project budget activity to ensure compliance with CIMR & sponsor policies and guidelines,
  • reviewing and approving research expenditures, preparing monthly projection reports, and preparing various post-award requests to sponsors (e.g., no-cost extension requests, re-budget requests, financial reports).

See our research grant process.





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Contact

CIMR is located in the heart of Silicon Valley at:

2260 Clove Dr.
San Jose, Ca 95128
Tel: 408-998-4554
Fax: 408-998-2723
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