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CIMR Researchers Awarded for Studies of the Development of a Fungal Vaccine

San Jose, CA - June 17, 2014 - The California Institute for Medical Research (CIMR), a non-profit organization, received notification on June 10 from the National Institutes of Health that a group of its researchers have received an award for studies of the development of a fungal vaccine. Fungal microbes cause disease in both healthy and immune-compromised persons, and are frequently fatal. Successful development of a vaccine could prevent such infections, and lessen the need for difficult and costly treatment.

The award enables continuation of a collaboration between the CIMR researchers and Biothera, a biotechnology company in Eagan, Minnesota. The CIMR researchers include Drs. David Read more

 

Cystic Fibrosis Research Award Given to California Institute for Medical Research

San Jose, CA - February 19, 2014 - The California Institute for Medical Research (CIMR) today announced that a group of its researchers have won an award for studies on the role of microbes in the progression of lung disease in the genetic disorder, cystic fibrosis (CF). Cystic fibrosis is a lethal disease (1 in 4000 births, over 70,000 persons worldwide) that is marked by disease in many organ systems, especially the lung.

The CIMR researchers are studying the disease roles of Aspergillus, a common fungus, and Pseudomonas, a common bacterium; these two microbes commonly persistently infect CF patient airways.  Read more

Valley Fever on the Rise

San Francisco Chronicle (CA)-­‐March 31, 2013 Author: Erin Allday

Large swaths of California, as far north as Redding and down to San Diego, have seen a dramatic spike in Valley Fever, a fungal infection that causes flu-­‐like symptoms and can be deadly. Cases of the illness in California rose about 13 percent per year every year from 1998 to 2011, according to a new report by the U.S. Centers for Disease Control and Prevention. There were 719 cases in 1998 and 5,697 in 2011. Read more

Dr. David Stevens is recognized among Castle Connolly's Top Doctors® for San Jose, CA 

A San Jose, CA Board Certified physician specializing in Infectious Disease, Dr. David Stevens, is a Castle Connolly Top Doctor.

San Jose, CA (PR Newswire) November 20, 2012 - Castle Connolly Medical Ltd., America's trusted source for identifying Top Doctors, has selected San Jose's Infectious Disease specialist Dr. David Stevens for inclusion in its highly selective list of Regional Top Doctors.

Castle Connolly Medical Ltd. publishes its list of Castle Connolly Top Doctors® at castleconnolly.com, as well as in a wide variety of printed directories, partner publications and on partner/affiliate websites including US News and World Report's annually updated list of "Top Doctors." All told, fewer than 35,000 physicians - less than 5% of the nation's licensed physicians - have been selected as Castle Connolly Top Doctors in their regions for their specialties.  Read more 

CIMR Grant for AIDS Research
The California Institute for Medical Research announces a grant in aid of research on AIDS to Dr. Michele Tang. The funding for this award came from the Burt W. and Virginia Polin Charitable Gift Fund, and was designated for AIDS research.  Dr. Tang's application was entitled "Developing a model of asymptomatic and reactivated cryptococcal disease in AIDS". The Cryptococcus is an opportunistic microbe that also infects healthy persons, and is particularly devastating when infecting persons whose immunity is impaired by diseases such as AIDS or a malignancy, or who receive immune suppressive drugs, such as steroids, for a variety of illnesses. It causes over 600,000 deaths globally every year. Her work will contribute to improving defenses against these infections.  Read more
 
 
Baker’s yeast protects against fatal infections
Injecting mice with simple baker’s yeast protects against the fatal fungal infection, aspergillosis, according to research published in the Journal of Medical Microbiology. The work could lead to the development of a human vaccine that protects immunocompromised people against a range of life-threatening fungal infections, for which current therapy often fails.
 
Researchers from the California Institute for Medical Research, Santa Clara Valley Medical Center and Stanford University gave mice three injections of killed Saccharomyces (baker’s yeast), one week apart. Vaccinated mice were able to survive high doses of Aspergillus – the fungus that causes aspergillosis. Mice that survived also showed a reduced infection load in their organs. Read more




Grant received from Gilead Sciences for Chagas Disease research
The California Institute for Medical Research (CIMR), San Jose is pleased to announce the award of a grant from Gilead Sciences to support an international team of researchers, to develop a new therapy for a parasitic disease of the Americas. The disease is caused by the parasite Trypanosoma cruzi, and is also known as “Chagas’ disease” (for its Brazilian discoverer, over 100 years ago). The disease principally affects the blood, heart and gastrointestinal tract, and is carried by a biting insect. It is estimated 14-16 million people are currently infected worldwide, mostly in Latin America, although there are 300,000 persons infected in the USA. Current treatments are prolonged, toxic and incompletely effective. Read more