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Major contributions by CIMR researchers past and present:
Infectious Disease David A. Stevens, MD Dr. Stevens is known internationally for his laboratory’s work in studying the body’s immune system and developing drugs to treat fungal infections. Other important studies have included the effects of chemical compounds as drug treatments against fungi that cause human and animal diseases; the immune response of the body to infection and methods to enhance response by molecules produced by DNA technology; and studies of interaction of human hormones and fungi and how this may affect diseases.
Infectious Disease Paul L. Williams, MD Our commuting Dr. Williams of Visalia is pursuing research in valley fever meningitis, a fungus that infects thousands of people a year in the Southwestern United States. By studying its cause, the immune response, complications and its treatment, the goal is to prevent fungal infection before it occurs.
Molecular Carcinogenesis John Leavitt, PhD Ching-Shwun Lin, PhD Dr. Leavitt’s research program has been recognized worldwide for the discovery and isolation of a unique set of human genes that appear to play critical roles in the development of human cancer. The study of these genes should eventually explain some of the key steps in the multi-step process of human tumor development. Their research may also lead to better tests for the early detection of human cancer and possibly a test for the early detection of AIDS virus infection in white blood cells.
Hematology/Drug Interactions Robert O’Reilly, MD Dr. O’Reilly has done pioneering research on the way drugs work in man and how different drugs interact. He has studied the interactions of drugs by comparing the effects of the anticoagulant drug taken alone with the effects of the anticoagulant taken with a secondary drug. His findings, widely used as guidelines by prescribing physicians, have had a major impact on the treatment of heart attack and stroke victims.
Clinical Neurophysiology—Vision/Eye Movement John Hotson, MD Dr. Hotson is one of the leading researchers in the emerging area of vision research and the study of eye movements. His focus has been on studying the complex subsystems of the brain that carry out the important visuomotor functions. These studies have helped clinicians to understand the extent of brain damage caused by certain forms of stroke and suggest how the patient’s impairment of vision and eye motor control may be overcome.
Parkinson’s Disease J. William Langston, MD Dr. Langston’s internationally acclaimed research has led to the first major breakthroughs in unraveling the mysteries of Parkinson’s Disease and the first real hope for a cure. Pursuing an intense search to identify MPTP and other MPTP-like compounds (such as pesticides) in the environment and comparing their locations with the incidence of the disease and that susceptibility to MPTP increase with age, may lead to answers not only in Parkinson’s Disease, but also in Alzheimers and other diseases of aging. Continuing his research Dr. Langston has been able to establish the Parkinson’s Institute located in Sunnyvale, California.
Urology Rodney Anderson, MD Dr. Anderson’s laboratory has been involved in two research projects focusing on a treatment method for urinary bladder cancer and the prevention of urinary tract dysfunction. Historically, urinary bladder cancer has been very difficult to treat with chemotherapy, often requiring surgical removal of the bladder. Through the use of small natural biologic substances known as liposomes, Dr. Anderson has been able to contain chemotherapy and deliver it directly to the tumor area once the area is heated. The second research project has involved the prevention and treatment of urinary tract infections that occur commonly among patients with spinal cord and head injuries.
Nutrition Patrick J. Kearns, MD Dr. Kearns is involved in the study of the use of electromagnetic stimulation to examine nutritional status and effects of nourishment on metabolism.
Disease Prevention Raxit J. Jariwalla, PhD Dr. Jariwalla is a principal research investigator in viral, immune and metabolic diseases. Listed in American Men and Women of Science, Dr. Jariwalla and his colleagues are recognized for their discovery of cancer-inducing ("transforming") genes in human herpes viruses, identification of anti-tumor and lipid-lowering properties in the phyto-nutrient, inositol hexaphosphate (IP6 or phytate) and the demonstration of HIV suppression of biological antioxidants such as ascorbic acid and thiols (eg. N-acetyl cysteine).
Urology Jeffrey Reese, MD Dr. Reese is clinical associate professor of Urology at Stanford University School of Medicine and Chief, Divison of Urology at Santa Clara Medical Center. His research interests include surgical and medical treatments for patients with benign prostatic hyperplasia, prostate cancer and urologic oncology, and the treatment of erectile dysfunction. Studies include an evaluation of the Indigo 830E Laser System for BPH including urodynamic evaluation before and after surgery and a phase II open-label study to evaluate the safety and activity of intravenous 3622W94 for the treatment of patients with hormone refractory prostate cancer MA1A2001. Glaxo-Wellcome.
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