CIMR Internationally Recognized Research

More than 300 research programs have been conducted at CIMR by award winning researchers.  This has resulted in internationally recognized discoveries in medicine and medical care. These have included:

  • improving the treatment of fungal diseases such as Valley Fever
  • preventing recurrent heart attack and stroke
  • developing an animal model of Parkinson’s disease
  • studying the influence of genetics on developing cancer.
  • identifying naturally-occuring organic compounds with anti-cancer activity (from nutritional studies in cancer)
  • investigating immune restoration by biological antioxidants (such as lipoic acid) in AIDS (from nutritional studies in AIDS)

CIMR researchers have also advanced the understanding of how the brain and spinal cord respond to neurological disorders, and developed a direct physiologic measurement of neurological processes that are critical to recovery from stroke and traumatic brain injury.

In addition, HIV physician-researchers have provided Santa Clara Valley Medical Center patients access to clinical trial studies, including adherence and treatment strategies, prophylaxis and treatment of various opportunistic infections, and viral vaccine trials.

The Neurology Research Laboratory has completed a series of experiments demonstrating substantial neuroplasticity of the part of the adult brain that produces vision. These findings suggest an intrinsic mechanism that can potentially help repair visual loss after stroke or injury to the visual brain.

The Infectious Diseases Laboratory continues to make significant progress in the treatment of fungal infections, performing in vitro and in vivo studies on novel compounds and testing licensed conventional antifungals alone and in combination.  Studies of molecular epidemiology of the mycoses, of host defenses against fungal infections (including the possibility of immunomodulation) and of vaccine development are areas of extensive effort. 

Work is ongoing into the study of Chagas' disease, a parasitic disease centered in Latin America, but spreading to the United States. Cardiac complications of this disease are studied by the use of human stem cells. 

Research Highlight

Injecting mice with simple baker’s yeast protects against the fatal fungal infection, aspergillosis, according to research published in the Journal of Medical Microbiology. The work could lead to the development of a human vaccine that protects immunocompromised people against a range of life-threatening fungal infections, for which current therapy often fails.

Researchers from the California Institute for Medical Research (Dr. David Stevens' research team), Santa Clara Valley Medical Center and Stanford University gave mice three injections of killed Saccharomyces (baker’s yeast), one week apart. Vaccinated mice were able to survive high doses of Aspergillus – the fungus that causes aspergillosis. Mice that survived also showed a reduced infection load in their organs. To view full press release, click here

This research group is currently working intently on CYSTIC FIBROSIS (C.F.), and the role played by two microbes, Pseudomonas & Aspergillus, in causing deterioration of patient airway function. The aim is to improve survival and quality of life in C.F. patients.




CIMR is located in the heart of Silicon Valley at:

2260 Clove Dr.
San Jose, Ca 95128
Tel: 408-998-4554
Fax: 408-998-2723